Melanoma is one of the most serious types of skin cancer. One of the reasons that melanoma is classified as a serious skin cancer is that it can spread to other parts of the body.
Your skin is made up of three layers:
- Epidermis – the outermost layer of skin
- Dermis – the middle layer containing blood vessels and connective tissue
- Hypodermis – the bottom layer of fat
The outer layer of the skin (epidermis) contains specialized cells called melanocytes that produce our skin's pigment (natural coloring). Melanoma occurs when these melanocytes begin multiplying out of control and form a cancerous tumor.
Facts About Melanoma
Patients can develop melanoma from an existing non-cancerous mole — you would begin to notice changes in your mole's appearance. But you may also see a new mole that looks different from your other moles.
Did you know that melanoma can occur anywhere on your body? Not only does melanoma develop on your arms and legs, but it can also develop on your scalp, under your fingernails, in your genital area, and even on the soles of your feet.
Melanoma may rarely develop in the body's mucous membranes, including the eye, anus, and vagina. An estimated 234,680 new cases of melanoma will be diagnosed in the United States in 2026, according to the American Academy of Dermatology.
Risk Factors for Melanoma
If you have one of these risk factors for melanoma, it's sensible to begin skin self-exams. Just as with other kinds of cancer, early detection saves lives. Here are some of the risk factors for melanoma.
- Sun exposure. Living at higher altitudes or in areas where the sun shines brightly year-round puts you at higher risk of skin cancer. People who regularly work outdoors are at increased risk, too.
- Sunburns. Just five sunburns in your life double your risk for melanoma.
- Indoor tanning. Tanning beds put you at a greater risk for developing melanoma and other skin cancers.
- Moles. If you have a lot of moles, or moles called dysplastic nevi, you are at increased risk for melanoma.
- Fair skin. People with fair skin, blue or green eyes, blond or red hair, freckles, or skin that burns easily have a higher risk for melanoma.
- Family history. If you have a first-degree relative (mother, father, brother, sister, or child) who has melanoma, you have a 2 to 3 times higher risk than average of developing melanoma. This risk might be due to where you live, whether it is at a higher elevation or near the equator. And if you have close family members who live in different places and develop melanoma, your risk is increased further.
- Previous history of skin cancer. If you've had basal cell or squamous cell skin cancer, you are at increased risk for melanoma.
- Race. White individuals have a significantly higher risk of developing melanoma than Black individuals, with incidence rates approximately 30 times higher.
Age is sometimes considered a risk factor. However, the truth is that melanoma happens in every age group, even teenagers. About half of melanoma diagnoses occur in adults over 50, but the disease can affect people of all ages. Melanoma is more common in young adults than in many other kinds of cancer. Before age 50, melanoma is more common in women; after 50, it's more common in men.
Tips for Skin Self-Exams
Experts recommend a monthly skin exam. A monthly self-exam helps you become familiar with the appearance of your moles so you can detect changes. The monthly exam will also help you detect new moles.
The ABCDE guidelines are an easy and convenient way to conduct your monthly skin exam. Watch the video to learn about the warning signs of melanoma.
- A – Asymmetry. If you look at a melanoma mole, the halves don't match. The left edge may be shaped differently than the right edge, or one side of your mole might be darker than the other side.
- B – Border. Melanomas have an irregular-shaped border; the border may be blurred, jagged, notched, or scalloped.
- C – Color. Moles that contain different colors may be melanoma. You might see several shades of brown or tan mixed with patches of black. Larger melanomas can develop patches of blue, pink, red, or white.
- D – Diameter or Dark. Moles that are larger than one-quarter inch (the diameter of a pencil eraser) could be melanoma. Be on the alert if one mole is significantly darker than your other moles.
- E – Evolving. Evolving means changing or progressing — in size, shape, or color, or it becomes itchy or begins bleeding.
Take notice, too, of an Ugly Duckling — a mole that is significantly different from nearby moles. A melanoma may stand out from other moles because it's darker, lighter, bigger, or smaller. A single mole on a large area of your skin with no other moles is considered an "ugly duckling," too.
About one-quarter of melanomas develop from existing moles. An astonishing 75% appear as new growths on the skin.
People of color are more likely to develop melanomas in areas that aren't exposed to the sun. They are more likely to have melanoma on the palm of their hand, the sole of their foot, or beneath a fingernail or toenail.
🔍You can download our version of a skin cancer body map to get you started!
Early detection is key — the five-year survival rate is 99% when melanoma is detected early.
Three Apps That Can Help You Track Skin Changes
There are several ways that you could keep track of your moles and other skin changes. The old-school way was to have a paper “body map” to mark moles, growths, or other suspicious spots. Many people choose to continue using the paper method, and that’s perfectly fine. However, there are other options if you’d prefer to keep your records digitally, including smartphone apps.
Several smartphone apps can help you keep track of skin changes and changes in specific moles. These apps are helpful, but they do not take the place of seeing a dermatologist when you detect moles that look suspicious. Always remember that it's better to err on the side of getting a dermatologist to look at any skin growth that looks different or pops up and quickly grows.
These apps are available for Apple and Android phones.
- Skinive
Skinive is an AI-powered skin monitoring app that helps users perform regular skin self-checks and track changes over time. The app provides real-time camera guidance to capture clear images and offers 3D mole mapping to help monitor skin changes. - MoleMapper
The MoleMapper™ Mole Tracking App is the result of a cancer biologist's efforts to help his wife. Oregon Health & Science University collaborated with Apple and Sage Bionetworks to develop this app. It's available at no cost. OHSU guides physicians to help monitor suspicious lesions without monthly in-person visits. Only available on Apple. - MoleScope
Users must purchase a device that attaches to their smartphone. Photos taken with the attachment are sent to a dermatologist for an online opinion.
Early detection of suspicious moles saves lives and helps prevent disfigurement for a patient who waited too long to see a dermatologist. Be sure to incorporate a monthly skin self-exam into your routine.
Originally published November 2020. Updated October 2026.